Anti-chan is part of the broader 'Moe-anthropomorphism' trend where internet users personify abstract concepts, movements, or events as cute anime-style girls. Emerging alongside characters like Earth-chan and Corona-chan, Anti-chan typically personifies skepticism towards mainstream science or medicine, often depicted with a mix of innocence and chaotic energy. The character gained traction on platforms like 4chan and Reddit, where artists used her to illustrate the absurdity of certain ideologies or simply to add an anime flair to contemporary debates. Today, she is used in various contexts, ranging from lighthearted anime fan art to sharp satirical memes about online misinformation.